The Museum of Melos is housed in a neo-classical building of 1870, the work of E. Ziller. It was restored by architects of the 21st Ephorate of Prehistoric and Classical Antiquities, and functions as a museum since 1985.

The museum includes the following collections:

- Prehistoric finds from Pylakopi,

- Sculptures and reliefs,

- Obsidian tools and other pieces,

- Inscriptions.