This is the most important of the sanctuaries dedicated to Hera.

The first, small-scale excavation of the site was conducted by Joseph Pitton de Tournefort (doctor and botanist) in 1702. In the 18th and 19th centuries, travellers visited the sanctuary and made drawings of the remains of the temple.

In 1879, at the NE corner, Paul Girard discovered the statue of "Hera" of Cheramyes, now exhibited in the Louvre.

In 1902 and 1903 the sanctuary was again excavated by the Archaeological Society of Athens, under the direction of P. Kavvadias and Th. Sophoulis. In 1910 it was further investigated by Th. Wiegand and M. Schede on behalf of the Koenigliche Museen of Berlin but work was interrupted in 1914 by World War I.

Systematic excavations were begun in 1925 by the German Archaeological Institute at Athens, under the direction of E. Buschor, were again interrupted in 1939 by World War II, resumed in 1951 and have been continued since then.