The first habitation of the site dates from the Neolithic and Early Minoan period (3rd millenium B.C.). In the late Classical period (beginning of the 4th century B.C.) the Gortynians established the sanctuary of Asklepios at the harbour. During the tremendous earthquake of 46 B.C. the city was destroyed and subsequently rebuilt. In the Early Christian and Byzantine periods, a small settlement developed and the basilica was erected. The small Byzantine church of St. John was built in the 14th century.