The archaeological investigation of the site started after the first visit of the English captain H. Spratt, in the middle of the 19th century. Excavations were carried out by the Italian Archaeological School at Athens in 1900, 1910 and 1912-13, and revealed the sanctuary and other buildings. Since then no excavation had taken place in the ancient city until recent years, when the investigations of the Greek Archaeological Service brought to light the Minoan settlement and graves.

The most important monuments of the site are:

1) The Temple of Asklepios. It lies at the SW edge of the terrace of the sanctuary and dates from the 1st-2nd centuries A.D. The walls, built of mudbricks with a revetment of white marble, are preserved to a height of 3.40 m. Two of the marble columns and the bases of the cult statues of Asklepios and Hygeia are preserved inside the temple.

2) The "Treasury". It is earlier than the temple and the west portico, lying beneath the floor of the latter. It was built in the Hellenistic period (3rd century B.C.) and its floor is covered with mosaics, forming two "panels" depicting a seahorse and palmettes. The mosaic covered the mouth of the "Treasury" (a well 1.90 m. deep, where the offerings were kept).

3) The Fountain, located to the south of the Nymphaion.

4) Large, three-aisled basilica. Ruins of the church, dated earlier than the 9th century A.D., were found underneath the basilica of St. John.

5) Early Minoan settlement (2600-2000 B.C.) on the low hill called Anginaropapouro.

6) The West Stoa. It extends to the north of the temple and is almost 27 m. long. In the northern part are preserved the thresholds of three doorways leading to rooms on the west, which were probably used by the priests and the temple personnel. The West Stoa and the temple were built in the period of the heyday of the Roman Empire (1st-2nd century A.D.).

7) The North Stoa. It was built before the temple (2nd century B.C.), into which it was later incorporated. Bases and parts of columns along with marble slabs are preserved. Most likely it was the "adyton" or "abaton" (sanctuary) of the shrine.

8) The Nymphaion. Room with two arches built of mudbricks, located at the east edge of the North Stoa.

9) Two large, mudbrick cisterns, used possibly for therapeutic baths.